pentobarbital will lower the extent or effect of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.pentobarbital decreases levels of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay clear of coadministration with potent CYP3A4 inducers; these drugs lower public